Treatment of Acid-related Diseases Using Potassium-competitive Acid Blockers
Proton pump inhibitors (PPIs) have several limitations to their efficacy including insufficient acid suppression, slow onset of action, and variable efficacy among patients due to CYP2C19 metabolism.Potassium-competitive acid blockers inhibit H+-K+-ATPase in 76% MINT CHOC BAR a reversible and K+-competitive manner, are novel acid suppressive drugs